I had probs with one of the disks too. I tried it in my CD Writer drive instead (after giving it a wipe) and it worked fine.
Game interface is very weird after PC games. Just need to (1) think game console (2) burn the mouse and (3) REMOVE THE WINDOWS KEY ! and you'll be fine
I'm running with the default keyboard settings (most stuff done with the num pad) and am doing fine. But then I never was a WASD FPS type. Even used the mouse in PlanetSide (I had very weird kepmappings, but still kicked ass..)